Detecting dominant QTL with variance component analysis in simulated pedigrees
نویسندگان
چکیده
منابع مشابه
Detecting dominant QTL with variance component analysis in simulated pedigrees.
Dominance is an important source of variation in complex traits. Here, we have carried out the first thorough investigation of quantitative trait locus (QTL) detection using variance component (VC) models extended to incorporate both additive and dominant QTL effects. Simulation results showed that the empirical distribution of the test statistic when testing for dominant QTL effects did not be...
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Variance component linkage analysis is commonly used to map quantitative trait loci (QTLs) in general pedigrees. Large pedigrees are especially attractive for these studies because they provide greater power per genotyped individual than small pedigrees. We propose accurate and computationally efficient methods to calculate the analytical power of variance component linkage analysis that can ac...
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ژورنال
عنوان ژورنال: Genetics Research
سال: 2008
ISSN: 0016-6723,1469-5073
DOI: 10.1017/s0016672308009336